The Ultimate Guide: Does Creatine Have Caffeine In It?

If you’re into working out or wanting to improve your athletic abilities, chances are you’ve come across two popular supplements: creatine and caffeine. They’re pretty well-known in the fitness world! 

It’s likely that it will be challenging to distinguish fact from fiction in today’s world with so much information.

That’s where this article arrives in. In this complete guide, we’ll take a deep jump into the world of creatine and caffeine, replying to a few of the most common questions individuals have about these typical supplements. 

We’ll also clarify straightforwardly whether creatine has caffeine or not. This article has something for everyone, regardless of your level of fitness and dedication.

Decades have passed since creatine and caffeine became synonymous with athletic performance and bodybuilding culture. This article delves deep into these tried and true supplements, aiming to provide a comprehensive understanding of them both and whether it’s secure and practical to consume them together.

Does creatine have caffeine in it?

Creatine does not have caffeine. Creatine and caffeine are different substances. Creatine is an amino acid aiding energy production in muscles, while caffeine is a stimulant found in beverages like coffee and energy drinks. Some pre workouts may have both, but they are not the same.

If you’ve been wondering whether creatine has caffeine or not, you’re just not alone. Numerous individuals mistakenly accept that creatine supplements have caffeine, but in reality, this is not the case.

The popularity of caffeine and creatine in enhancing physical performance has been prevalent for a long time among athletes and trainers alike. 

It is essential to note that while these two supplements have a similar objective of improving athletic performance; yet, their properties offer different benefits and limitations impacting various aspects of our physiology.

Caffeine is a stimulant that can improve sharpness and energy [1, 2], while creatine is an amino acid that creates a contrast in performance amid high-intensity workouts [3, 4].

It’s elemental to state that not all supplements are made equal, and it’s vital to check the ingredient labels to be sure of everything. While some pre workout supplements may have both creatine and caffeine, you can also find standalone creatine supplements that are completely caffeine free.

Fitness enthusiasts understand the significance of careful selection when it comes to supplements that complement their workout routine. 

If your primary focus is on boosting your strength and power yield, at that point, you will find that creatine is the better supplement for you to take. On the other hand, if you’re trying to find a fast energy boost, at that point caffeine is a more suitable option.

Takeaway: While creatine and caffeine are both popular supplements in fitness, they are different substances, and creatine supplements do not have caffeine. To make informed choices, it’s important to check ingredient labels and select supplements based on personal needs and goals.

Related: Creatine Vs Pre Workout – Differences and Which is Better?

What is creatine?

Of paramount importance during vigorous physical performance is the availability of creatine- a naturally occurring amino acid found notably in animal-based products such as fish and meat. 

By facilitating readily accessible energy stores within skeletal muscles utilized during explosive movements such as those executed during resistance training or sprints [3, 4}, administering supplementary doses of this compound yields beneficial outcomes for individuals seeking noticeable improvements in strength gains achieved through prolonged training regimes [5, 6].

In terms of increasing athletic performance through supplementation, various forms of creatine supplements exist today including those classified as monohydrate or ethyl ester-based options. 

But according to research studies carried out over time, the most commonly used and scientifically investigated version remains Creatine Monohydrate because of a proven record for both efficacy and safety [4].

It must be noted however that every person has different requirements depending upon their physical condition; hence individuals diagnosed with any underlying illnesses such as kidney-related complications may want first consult with their doctor before consuming any supplements. 

Related: Is Creatine Natty (Natural)? The Truth about Creatine

What is caffeine?

Caffeine is a prevalent stimulant found in beverages counting coffee, tea, and vitality drinks [7]. It works by stimulating the central nervous system, expanding alertness, and diminishing fatigue.

Although there exist several positive benefits attributed to moderate amounts of caffeine consumption namely higher attention level rates, and better cognitive thought processes, certain negative drawbacks are noted too. If not consumed within set limits, it can trigger unwanted symptoms like intense jitters, insomnia symptoms, etc [8, 9].

The amount of caffeine you can safely consume depends on different components, which involve your age, weight, and common well-being.  Caffeine ingestion should not exceed the FDA’s recommended limit of 400 mg per day- about four cups worth of coffee content-wise. 

It’s again important to note that caffeine can have a different effect on each individual. Some individuals are more sensitive to caffeine than others and may experience negative side effects even with little sums of caffeine. 

It’s absolute to listen to your body and pay consideration to how you’re feeling after consuming caffeine.

Creatine Vs Caffeine

creatine and caffeine

Creatine and caffeine are both used in fitness and sports nutrition but are different substances. Creatine is a natural amino acid that boosts muscle energy, whereas caffeine is a stimulant that enhances mental focus and energy levels. 

Their effects vary and they should be chosen according to personal needs and objectives.

Creatine is basically used to increase muscle strength and control because it gives energy to the muscles amid high-intensity workouts. It works by increasing the production of ATP [10, 11], the molecule that provides energy to our cells while doing any work. 

Creatine has been broadly studied and has been found to be secure and compelling for increasing muscle strength and power, particularly in conjunction with resistance training. 

Whereas caffeine is a stimulant that influences the central nervous system to provide bursts of energy [12].  It is commonly consumed to increase alertness and decrease weakness and is found in a variety of sources counting coffee, tea, energy drinks, and supplements.

It works by blocking the action of adenosine, a neurotransmitter that promotes relaxation and sleepiness, leading to increased wakefulness [13].

In terms of their effects on the body, creatine, and caffeine work in different ways and have different benefits.  However, both supplements can have positive effects on athletic performance and can be used jointly in certain situations.

It’s critical to note that the impacts of creatine and caffeine can vary depending on the individual and some particular circumstances. It’s possible that people will have unique preferences for either creatine or caffeine supplementation depending on their body’s response or how they choose to combine them.

Related: Creatine Vs Fat Burners – Differences and Similarities 

Can you take creatine and caffeine together?

does creatine have caffeine

Many people wonder if it is safe and effective to take creatine and caffeine together.  Some believe that combining the two supplements can provide even greater benefits than taking them separately.

To begin with, it is vital to note that creatine and caffeine work in different ways. Creatine helps the body produce more energy by increasing the generation of ATP molecules, whereas caffeine stimulates the central nervous system and improves alertness and focus.

There is some conflicting information about whether combining creatine and caffeine supplements enhances athletic performance or not. 

A systematic review [14] of 10 studies found that taking creatine before an acute dose of caffeine before exercise did not affect the benefits of caffeine, but taking both supplements chronically may interfere with the benefits of creatine. 

Some possible reasons for this include differences in relaxation time and gastrointestinal issues. Overall, the proof is mixed, and more research is required to decide the perfect way to utilize these supplements together.

It is further worth stating that combining creatine and caffeine may raise the chance of dehydration, as caffeine can have a diuretic effect on the body. If you do choose to take creatine and caffeine together, it is required to do so in a secure and mindful manner.

Start with smaller doses and slowly increase as tolerated. Be sure to stay hydrated and observe how your body reacts to the mixture of supplements.

Related: Can You Mix Pre Workout With Protein Powder? Is It Suitable?



In the end, it’s crucial to mention that creatine and caffeine are two separate supplements that serve different purposes. While creatine is primarily used to enhance athletic performance, caffeine is a stimulant that delivers a boost of energy. 

It’s moreover important to report that creatine supplements do not have caffeine, so there’s no need to stress about complicating the two.

Here are the main takeaways from this article:

  • Creatine and caffeine are not the same things, and creatine supplements do not normally have caffeine.
  • Creatine can improve muscle mass and athletic performance, while caffeine provides a boost of energy.
  • Creatine and caffeine work differently in the body, so there may be situations where one is preferable to the other.
  • Taking creatine and caffeine concurrently generally poses no threat to users; nevertheless, it cannot be denied that such a regimen might give rise to certain unfavorable consequences.
  • Depending on personal factors and individual experiences, people may discover unique benefits from combining these two nutrients or they could encounter unwanted reactions to their simultaneous usage.

Remember to always review the ingredient labels of any supplements you are considering taking and consult with a healthcare specialist before adding anything new to your routine. 

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  2. Smith A. Effects of caffeine on human behavior. Food Chem Toxicol. 2002 Sep;40(9):1243-55. doi: 10.1016/s0278-6915(02)00096-0. PMID: 12204388.
  3. Tarnopolsky MA, MacLennan DP. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr Exerc Metab. 2000 Dec;10(4):452-63. doi: 10.1123/ijsnem.10.4.452. PMID: 11099372.
  4. Hall M, Trojian TH. Creatine supplementation. Curr Sports Med Rep. 2013 Jul-Aug;12(4):240-4. doi: 10.1249/JSR.0b013e31829cdff2. PMID: 23851411.
  5. Cooper R, Naclerio F, Allgrove J, Jimenez A. Creatine supplementation with specific view to exercise/sports performance: an update. J Int Soc Sports Nutr. 2012 Jul 20;9(1):33. doi: 10.1186/1550-2783-9-33. PMID: 22817979; PMCID: PMC3407788.
  6. Kreider, R.B., Kalman, D.S., Antonio, J. et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. J Int Soc Sports Nutr 14, 18 (2017).
  7. Evans J, Richards JR, Battisti AS. Caffeine. 2022 Nov 28. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30137774.
  8. Richards G, Smith A. Caffeine consumption and self-assessed stress, anxiety, and depression in secondary school children. J Psychopharmacol. 2015 Dec;29(12):1236-47. doi: 10.1177/0269881115612404. Epub 2015 Oct 27. PMID: 26508718; PMCID: PMC4668773.
  9. Clark I, Landolt HP. Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials. Sleep Med Rev. 2017 Feb;31:70-78. doi: 10.1016/j.smrv.2016.01.006. Epub 2016 Jan 30. PMID: 26899133.
  10. Zange J, Kornblum C, Müller K, Kurtscheid S, Heck H, Schröder R, Grehl T, Vorgerd M. Creatine supplementation results in elevated phosphocreatine/adenosine triphosphate (ATP) ratios in the calf muscle of athletes but not in patients with myopathies. Ann Neurol. 2002 Jul;52(1):126; author reply 126-7. doi: 10.1002/ana.10197. PMID: 12112063.
  11. Kurosawa Y, Hamaoka T, Katsumura T, Kuwamori M, Kimura N, Sako T, Chance B. Creatine supplementation enhances anaerobic ATP synthesis during a single 10 sec maximal handgrip exercise. Mol Cell Biochem. 2003 Feb;244(1-2):105-12. PMID: 12701817.
  12. Nehlig A, Daval JL, Debry G. Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Brain Res Rev. 1992 May-Aug;17(2):139-70. doi: 10.1016/0165-0173(92)90012-b. PMID: 1356551.
  13. Urry E, Landolt HP. Adenosine, caffeine, and performance: from cognitive neuroscience of sleep to sleep pharmacogenetics. Curr Top Behav Neurosci. 2015;25:331-66. doi: 10.1007/7854_2014_274. PMID: 24549722.
  14. Elosegui S, López-Seoane J, Martínez-Ferrán M, Pareja-Galeano H. Interaction Between Caffeine and Creatine When Used as Concurrent Ergogenic Supplements: A Systematic Review. Int J Sport Nutr Exerc Metab. 2022 Jan 11;32(4):285-295. doi: 10.1123/ijsnem.2021-0262. PMID: 35016154.

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